New Meta-Analysis in European Heart Journal’s Cardiovascular Pharmacotherapy Examines Cholesterol Ester Transfer Protein (CETP) Inhibitors’ Role in Reduction of Diabetes Risk

Dr. John Kastelein

NAARDEN, Netherlands & MIAMI– NewAmsterdam Pharma (NewAmsterdam), a clinical-stage company focused on the research and development of transformative therapies for metabolic diseases, today announced the publication of a new meta-analysis in the European Heart Journal’s publication Cardiovascular Pharmacotherapy, discussing the effect of cholesteryl ester transfer protein (CETP) inhibitors on new-onset diabetes. This research was co-authored by NewAmsterdam’s chief scientific officer, John Kastelein, M.D., Ph.D., Katerina Dangas, University of Oxford, and Dr. Ann Marie Navar, Department of Internal Medicine, University of Texas Southwestern Medical Center.

The analysis examines the effect CETP inhibitors have on reducing new-onset diabetes and related glycemic measures in patients. Trials have shown a consistent reduction in the risk of new-onset diabetes in patients using CETP inhibitor therapy, while use of statins has been shown to increase the risk of new-onset diabetes. In four randomized trials, CETP inhibitors significantly decreased the risk of new-onset diabetes by 16%, with low between-trial heterogeneity. CETP inhibitors also significantly improved or demonstrated a trend towards improvement in glycemic measures in those with and without diabetes.

“The results from this meta-analysis highlight the potential of NewAmsterdam’s CETP inhibitor, obicetrapib,” said Dr. John Kastelein, chief scientific officer of NewAmsterdam. “Obicetrapib, a novel, oral, once-daily, low-dose therapy, has the potential to play an important role in the treatment landscape for the lowering of low-density lipoprotein cholesterol (LDL-c), while increasing high-density lipoprotein cholesterol (HDL-c). The studies reviewed in this analysis demonstrated risk reduction in new-onset diabetes, highlighting another potential benefit of obicetrapib. Given the relationship between cardiovascular disease and diabetes, we are optimistic that obicetrapib can offer a differentiated product profile compared to existing standard of care, improving the overall health of patients on therapy by reducing both their risk of cardiovascular disease and diabetes.”

The publication concludes that future trials of CETP inhibitors and potentially other HDL-raising agents should evaluate new-onset diabetes and reversal of existing type II diabetes as secondary endpoints to further define the effect of this class on reducing new-onset disease.  NewAmsterdam is currently evaluating obicetrapib in two Phase 3 trials, BROADWAY and PREVAIL, and a secondary Phase 2 trial, ROSE2; one secondary objective of PREVAIL is to evaluate the effect of obicetrapib on new-onset diabetes mellitus.