SAN DIEGO, Calif.– n-Lorem, a nonprofit foundation, today announced the publication of an invited perspective article authored by n-Lorem founder and CEO, Dr. Stanley Crooke, and titled “Establishing an Environment in Which Rigorous Scientific Inquiry is Practiced” in Nucleic Acid Research (Crooke, S.T., NAR, Advanced Online Publication, July 2022). In this retrospective publication, the longevity and success of Ionis Pharmaceuticals is used to illustrate the unique challenges and rewards of establishing and fostering a corporate environment in which rigorous scientific enquiry is normal practice.
As a hands-on scientific leader his entire career, Dr. Crooke is credited with inventing, advancing and validating a new drug discovery platform, RNA-targeted drug discovery, and using this platform to discover and develop life-changing therapies. Over the course of his career, Dr. Crooke has led the discovery and development of hundreds of drugs, including more than 23 commercialized drugs, and published more than 500 scientific publications. This invited perspective allows the reader to understand the rationale, the hurdles and the rewards of founding and building an organization committed to the science, the collective pursuit of helping patients and performing the highest quality of science possible.
Dr. Crooke brings a lifetime of knowledge in advancing the understanding of RNA therapeutics creating a broadly enabling drug discovery and development platform to create a nonprofit model to meet the challenges of some of the rarest of rare patients, nano-rare patients (1 to 30 patients worldwide). n-Lorem is the culmination of this career and benefits from the integration of this powerful technology, a culture with a bias to always say ‘yes’, and the practice of rigorous quality at every step. n-Lorem is the first, mutational-driven, nonprofit foundation focused on meeting the challenges of some of the rarest of rare patients, nano-rare patients.
“NAR is one of the most highly regarded scientific journals with an impact factor of 17, a reflection of the importance of this journal in the field of nucleic acid research. I appreciate the interest of the journal in understanding the challenges of creating a rigorous scientific environment,” said Stanley T. Crooke, M.D., Ph.D., Founder, CEO and Chairman of n-Lorem Foundation. “Taking this experience and knowledge, I have created an equally rigorous science environment at n-Lorem, where we are discovering and developing personalized treatment options for nano-rare patients across the United States. Today we have more than 60 patients accepted into our program, but soon we anticipate having hundreds. With so many individualized drug discovery and development programs ongoing simultaneously, the quality and efficiencies that we have in place today will enable us to maintain the highest quality of science possible as we help more and more nano-rare patients.”
“The question of how to address difficult science programs, while maintaining the highest quality possible is one often faced by scientists,” said David Corey, Ph.D., Executive Editor, Nucleic Acids Research, Rusty Kelley Professor of Medical Sciences, Department of Pharmacology and Biochemistry at UT Southwestern Medical Center. “We hope that Dr. Crooke’s perspective will be a useful guide for those seeking to understand how to balance rigorous basic science with the practical demands of drug development. We expect that this Perspective will not only inspire scientists in industry, but also in academia.”
Both the Perspective “Establishing an environment in which rigorous scientific inquiry is practices: a personal journey” by Stanley T. Crooke and the accompanying Editorial “Critical reviews and perspectives in Nucleic Acids Research” by David R. Corey and Helle D. Ulrich are available now in the advanced article published online in July 2022 in Nucleic Acids Research.