BASEL, Switzerland– Alentis Therapeutics, AG today announced it has dosed the first cohort of healthy participants in a first-in-human Phase 1 clinical trial of ALE.F02, a monoclonal antibody highly selective for Claudin-1, currently being developed for the treatment of advanced unmet liver and kidney fibrosis. Alentis is a clinical stage biopharma focused on discovering and developing novel therapies for the treatment of unmet fibrotic diseases.
“ALE.F02 has demonstrated compelling safety and efficacy in preclinical patient-derived models of liver and kidney fibrosis. We look forward to further investigating this compound, in this dose-escalating Phase 1 study,” said Markus Meyer Ph.D, Vice President R&D. Roberto Iacone, CEO of Alentis Therapeutics added, “We believe our differentiated approach of inhibiting pathological overexpressed and conformation-dependent Claudin-1 epitopes in liver and kidney fibrosis holds the potential to reverse clinically advanced fibrosis.”
In the US and Europe alone, about 45% of deaths can be attributed to fibrotic disorders. Fibrosis affects nearly all tissues and organ systems such as the liver, kidneys, and lungs. Advanced liver fibrosis and associated cirrhosis is the fastest-growing indication for liver transplantation in the United States. While multiple investigational agents target mechanisms that impact the earlier metabolic stages of the fibrosis development, Alentis is targeting clinically advanced liver fibrosis associated with different etiologies through inhibition of Claudin-1, a recently discovered therapeutic target for organ fibrosis.
