TORONTO– Epineuron Technologies has announced positive topline results from a pilot study evaluating its PeriPulse® Nerve Stimulation System, a wearable device designed to aid recovery following peripheral nerve injuries. The findings, published in the journal Bioelectronic Medicine, suggest that the system may significantly accelerate nerve regeneration and improve patient outcomes.
The first-in-human study showed that 87.5% of patients treated with PeriPulse experienced clinically meaningful sensory improvement six months after injury, compared to their pre-surgery baseline. These early results highlight the potential of electrical stimulation as a powerful tool in the treatment of acute nerve injuries.
Peripheral nerve damage—particularly from trauma—remains a difficult condition to treat, with surgery often yielding slow and incomplete recovery. Epineuron’s PeriPulse system is designed to be deployed easily during surgery without adding time to the procedure. The device delivers targeted electrical stimulation therapy immediately after nerve repair to promote regeneration.
“This publication is a major milestone for our team,” said Dr. Mike Willand, co-founder and CTO of Epineuron. “It confirms our approach to nerve stimulation is not only effective but can be seamlessly integrated into surgical workflows.”
The system was well tolerated by patients, and no significant safety concerns were reported, according to the study. These promising results are now fueling a larger multinational clinical trial, REGAIN™, currently underway in Canada and the U.S. The trial is expected to support future FDA approval of the device.
“Better nerve regeneration is a game changer for patients,” said Dr. James Bain, Professor of Plastic Surgery at McMaster University and lead author of the study. “This system offers a practical, effective way to deliver electrical stimulation therapy without complicating surgery, and has the potential to transform care for patients with peripheral nerve injuries.”
The PeriPulse system could represent a new frontier in bioelectronic medicine, providing surgeons with an accessible and efficient tool to improve post-operative recovery for a patient population that currently faces limited options.
