Marlborough, Mass. — At the ASMS 2025 conference, SCIEX introduced the ZenoTOF 8600 system, its latest innovation in accurate mass spectrometry designed to redefine quantitation capabilities across omics research. Building on decades of leadership in analytical technologies, SCIEX’s newest addition to the ZenoTOF portfolio promises major gains in sensitivity, resolution, and structural insight—enabling scientists to quantify thousands of molecular species from complex biological samples with unprecedented speed and precision.
The ZenoTOF 8600 system incorporates advanced hardware features, including the OptiFlow Pro source, DJet and QJet ion guides, and an enhanced Zeno trap, which collectively deliver up to ten times greater sensitivity compared to its predecessor, the ZenoTOF 7600+. Additionally, the system introduces a new optical detector capable of handling higher ion currents and Mass Guard technology to reduce contamination and increase uptime.
These innovations are further amplified by ZT Scan DIA 2.0, SCIEX’s next-generation data-independent acquisition platform. With expanded mass range coverage, ZT Scan DIA 2.0 enhances quantification across all omics disciplines—transforming challenging molecular identifications into quantifiable targets. According to Dr. Nicola Zamboni of ETH Zurich, the new system not only improves sensitivity but also allows for complex analyses such as SWATH-type experiments on lipids and natural products, unlocking discovery biology at a new level.
To support the system’s expanded capabilities, SCIEX has also launched SCIEX OS version 4.0. This updated software offers faster, more automated workflows and integrates seamlessly with the ZenoTOF 8600 to boost operational efficiency, accuracy, and precision.
SCIEX is also deepening its partnerships in software innovation. A new collaboration with MS-Dial enhances support for untargeted metabolomics and lipidomics by improving spectral deconvolution and compound identification through open-source tools. MS-Dial now supports SCIEX raw data and is optimized for ZT Scan DIA workflows, providing researchers with greater analytical flexibility.
In proteomics, SCIEX continues its collaboration with Bioinformatics Solutions Inc. through the release of PEAKS Studio 13. This latest version improves the processing of data from ZT Scan DIA, SWATH DIA, and DDA scan modes, delivering deeper insights into peptide identification, protein inference, post-translational modifications, and sequence variants.
Jose Castro-Perez, Vice President of Product Management at SCIEX, said the new system and software collaborations represent a turning point for omics research. “What excites us most is the feedback from researchers who tell us they can now foresee real-world outcomes from the data and insights we’re enabling. The ZenoTOF 8600 is more than just a system—it’s a tool for discovery with real impact.”
With the launch of the ZenoTOF 8600, SCIEX is setting a new benchmark in mass spectrometry performance, providing researchers across proteomics, metabolomics, and other omics disciplines with the power to uncover biological insights at greater depth and scale.
