LIVERMORE, Calif. and TAIPEI, Taiwan — Syncell Inc., a nanoscopic proteomics company, has introduced the Synlight-Pure Kit, an ultra-high-precision photolabeling reagent designed for use with its Microscoop Mint platform. The new kit enables scientists to achieve subcellular proteomic discovery with 25-nanometer labeling precision, providing a powerful, unbiased approach to mapping protein interactions within cells and tissues.
The Synlight-Pure Kit allows researchers to identify all proteins within 25 nanometers of a microscopy-selected region of interest, enabling exceptionally high specificity for true discovery-driven studies. It complements Syncell’s Synlight-Rich Kit, offering a balance between high specificity and broad sensitivity, and does not require hardware or software upgrades. The system streamlines microscopy-guided protein purification and supports exploration at the molecular interaction level, capturing proteins in specific biological regions while minimizing off-target biotinylation and artifacts from engineered labeling methods.
Used together with the Microscoop Mint platform, the Synlight-Pure Kit enables high-resolution profiling of cellular and subcellular environments, including organelles, membranes, and inter-organelle interfaces. The technology is particularly effective for characterizing complex features such as cell-cell junctions and plasma membranes, which have historically been difficult to analyze due to their structural complexity. When integrated with LC–MS workflows, the combined system can identify thousands of proteins with remarkable precision, uncovering previously unknown targets relevant to drug discovery and disease biology.
“Protein–protein interactions are central to how cells function, and their dysregulation underlies many common diseases,” said Jung-Chi Liao, Ph.D., CEO and founder of Syncell. “Our new Synlight-Pure Kit together with the Microscoop Mint platform delivers significant performance advantages and achieves high-specificity subcellular proteomic discovery by double screening of image-based target selection and chemistry-based proximity selection. The approach empowers scientists to identify new key protein players for specific biological problems and diseases and to shed light on critical protein interactions that are challenging for existing techniques.”
Syncell’s Microscoop Mint platform integrates microscopy-guided photochemistry, precision mechatronics, and advanced biochemistry for nanoscopic-scale proteomic research. Fully compatible with mass spectrometry systems, it enables unbiased, spatially resolved protein discovery. Researchers are using the technology to drive progress in areas including drug target and biomarker discovery, neuroscience, oncology, immunology, and cellular biology—revealing previously hidden layers of biological complexity with nanometer-level precision.
