Aptorum Group Enters into an Agreement with Exeltis to Develop Aptorum’s Novel Preclinical Candidate

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Dr. Clark Cheng

NEW YORK & LONDON & PARIS– Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) (“Aptorum Group” or “Aptorum”), a clinical-stage biopharmaceutical company, has entered into an agreement with Exeltis (“Exeltis”) (a division of the global pharmaceutical group Insud Pharma) to develop, manufacture and commercialize a novel preclinical candidate from Aptorum in the following territories: the European Union and Latin America (with an option to expand the collaboration to the United States). This novel candidate is intended to target woman’s health and gynecological conditions, such as endometriosis or related conditions. Under the Agreement, Aptorum Group will retain the development rights in other jurisdictions in the world, as well as the right to develop the novel candidate into a drug product. Commercialisation of the product is subject to relevant regulatory approvals in their respective jurisdictions.

Dr. Clark Cheng, Chief Medical Officer and Executive Director of Aptorum Group, commented: “Endometriosis is a systemic gynecological condition that is often painful and chronic, estimated to affect approximately 10% of reproductive-age women1. Symptoms of endometriosis include, but are not limited to chronic pain and in extreme cases infertility, thereby placing significant physical, emotional and economical impact on the patients. Currently, the mainstay of treatment includes surgery and/or hormonal treatment with oral contraceptives, neither of which are ideal, especially for reproductive aged women suffering such disease2. We believe that the candidate’s non-hormonal approach has the potential to address such unmet needs and we are excited to partner with Exeltis to develop this product to provide patients with a viable alternative.”