DURHAM, N.C.– BioSkryb Genomics, a leader of single-cell genome amplification, and ALS Automated Lab Solutions GmbH, developers of a multi-patented spatial single cell and colony picking technology platform, today announced a U.S. distribution agreement to power comprehensive single cell plus spatial genomic analysis. The agreement was signed in December 2021. In addition, the partnership will develop single-cell genome analysis from intact tissue samples. The distribution agreement combines BioSkryb’s proprietary ResolveDNA™ technology with ALS CellCelector™ platform to drive single-cell genomic applications where the genome context matters.
Traditional “bulk” sequencing methods combine all cells of a tissue sample (e.g., a cancer biopsy) before sequencing and have persisted primarily due to the lack of quality DNA amplification from a single cell. Now with BioSkryb’s proprietary ResolveDNA technology combined with ALS CellCelector platform, researchers and clinicians can perform single-cell genomics from cells isolated at a specific location. The companies are collaborating to extend analysis of intact tissue specimens, where a single cell is selected from the organized cell structure and analyzed with high resolution genome analysis. This process is designed to maintain the cell context of their original environment and provides critical information for many fields, including oncology, cardiology, neurology, immunology, and preimplantation genetic testing, that could help guide diagnostics and treatment decisions.
“This will be a breakthrough for researchers and clinicians, and eventually for patients, because in one experiment, we will be able to achieve high resolution single-cell omics of critical cells, while retaining the context of where those cells interact with other cells and critical landmarks within the tissue sample,” said Jay West, Ph.D., CEO and Cofounder of BioSkryb. “With this expanded distribution agreement between BioSkryb and ALS, we will be offering an understanding of the ‘micro’ with the ‘macro” that can help accelerate genomic insights in the fields of pathology, diagnostics, and drug discovery, that can ultimately improve patient care.”
Jens Eberhardt, CEO and Cofounder of ALS added, “With this collaboration, we will enable researchers to benefit from the best in both worlds – market leading single cell isolation technology and best-in-class single cell analysis know-how and reagents. With this combined experience, we will be able to speed up knowledge and understanding of researchers and scientists that will ultimately benefit the patients soon.”
BioSkryb’s ResolveDNA products incorporate proprietary primary template-directed amplification (PTA) technology, which was created to address the inherent challenges of single-cell genomics by producing high-quality gene sequencing data. PTA technology employs controlled reaction parameters to reproducibly recover >95% of the genomes of single cells and low-input samples with high accuracy and uniformity. ResolveDNA products support sequencing library generation produced from limiting samples that have undergone whole genome amplification, resulting in the highest quality genetic analyses available today for many single-cell genomic applications.
